MY CV WILL BE UPDATED
WITH
DR. ANTHONY MELVIN CRASTO
Introduction
PH.D (ORGANIC CHEMISTRY) from UDCT, Mumbai, 1991, with over 32
years of result oriented Experience in Industry and 4 yrs academic (total 36 years). Presently, working with AFRICURE PHARMA as ADVISOR ALSO ROW2TECH, NIPER-G, CLEANCHEM LABS previous assignment was at Glenmark Lifesciences ltd as Consultant, Process research (API – Jan‘2022-Jan 2023)
Earlier organizations include :-
JOB PROFILE: To carry out research and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents , Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.
Personal Details :
Location : Mumbai (Thane)
Nationality : Indian
Date of Birth : 17th January, 1964
Marital Status : Married
Postal address : Vijay Nagari Annex, Bldg.26, Flat 34
Ghodbunder Road, Thane (W)-400 615 India.
Email I.D. [email protected]
Web : http://amcrasto.weebly.com/ http://newdrugapprovals.org/ (ctrl +click to follow link)
Residence. Tel +91-22-5972567/
Mobile :+91(country code)-9323115463/+91-9321316780
EDUCATION:
Ph.D – Organic Univ.Department of Chemical Technology, Matunga By Research
Chemistry – (1991) Bombay (Univ. of Bombay) India Thesis : Prof. S.Seshadri
Synthesis of Novel Pyrethroid Analogues.
M.Sc. - (Organic R. J. College, Ghatkopar, Securing 1st Class
Chemistry – (1986) Bombay (Univ. of Bombay) (65.50%)
B.Sc -.Chemistry R .J. College, Ghatkopar, Securing 1st Class
(1984) Bombay (Univ. of Bombay) (62.60%)
H.Sc (1981) R. J. College, Ghatkopar, Securing 1st Class
Bombay (Poona Board) (68.17%)
S.S.C (1979) St. Xavier`s high School, Securing 1st Class
Powai, Bombay (Poona Board) (69.29%)
OTHER COURSES:
years) total=36yrs
ALSO ROW2TECH, NIPER-G, CLEANCHEM LABS
Highlights in career
Expertise in the area of Process R&D (Generic API)
Development of new API for fresh DMF / CEP Filings for Regulated Markets (US, EU, Canada, Japan etc,).ü Expertise in Lab Development of New API for fresh DMF Filing for regulated markets. Execution of pre-scale up, scale-up and exhibit/validation batches of the new API. Technology Transfer from lab scale to kilo lab, Pilot plant scale and finally to plant scale for commercial Production. Process validation at plant scale to file DMF for regulated markets.
Hand on experience in the Cost reduction / Technology improvement of existing DMF filed APIs by Identifying areas of improvement for existing commercialized processes in all divisions with the objective of “increasing throughput, reducing the steps, recovering and recycling of spent solvents, minimizing waste, effluent generation, reducing cycle time, reducing the overheads corrections, recycles and improve process yield, and RM consumption, using cheaper RM’s, by changing the reaction scheme etc.,"
Expertise in plant level trouble shooting and also in trouble free technology development and Technology Transfer of API.
Expertise in Synthesis of impurities and impurities carry over study/ Genotoxic impurities evaluation / Addressing Regulatory / customer deficiency queries.
Well versed with ICH Guidelines, cGMP, USFDA & Regulatory requirements for various advanced markets like EU, US and Japan, also the regulatory requirements for fresh DMF filing and variation filing of existing process with FDA on existing process. Well versed on the DRA requirements on variation filing of the Technology Improved / cost reduction of existing / commercialized / DMF / CEP filed process.
Well versed with Para – IV Filing, FTF and also regulatory requirements for Drug Substances.
Articulate, dynamic leader with diverse blend of Process R&D / Process Improvement / Process development, tech transfer, Scale–up expertise of API. Well versed with QBD and implementing design of experiments for API Experience in training chemists and handlinfg all softwares needed for process research
Presently working with AFRICURE PHARMA as ADVISOR (FEB 2023 -PRESENT)
To create value addition to brand AFRICURE, Recommend technical talent, Identify joint ventures between Global companies/Indian and Africure to do business in Africa. Assist in locating tech and identifying to provide tech transfer. Refer Africure to relevant global companies and Indian programmes and get better visibility. Paticipate in aquisitions, mergers, tieup and identify them.
GLENMARK LIFESCIENCES LTD. - JAN ‘22 – JAN 2023API ,PROCESS RESEARCH
Currently with GLENMARK LIFESCIENCES LTD research centre as Consultant API) at Mahape ,Navi Mumbai,(Jan2022-present) and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
GLENMARK LIFESCIENCES LTD. - JAN ‘22 - 16.1 YRS , WorkedAPI ,PROCESS RESEARCH
Worked with GLENMARK LIFESCIENCES LTD research centre as Principal Scientist, process research (bulk actives) API) at Mahape ,Navi Mumbai,(dec05-present) and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
Currently, involved in development of 8 targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects
DR. ANTHONY MELVIN CRASTO
Introduction
PH.D (ORGANIC CHEMISTRY) from UDCT, Mumbai, 1991, with over 32
years of result oriented Experience in Industry and 4 yrs academic (total 36 years). Presently, working with AFRICURE PHARMA as ADVISOR ALSO ROW2TECH, NIPER-G, CLEANCHEM LABS previous assignment was at Glenmark Lifesciences ltd as Consultant, Process research (API – Jan‘2022-Jan 2023)
Earlier organizations include :-
- GLENMARK LIFESCIENCES ( 17YRS )
- INNOVASSYNTH Tech Ltd (2.7 yrs),
- RPG Life Sciences (5.7yrs),
- HOECHST MARION ROUSSEL (GMP dept,7 months),
- HOECHST MARION ROUSSEL (Process Devl. dept, 4 years),
- SEARLE INDIA Ltd (1.7 yrs),
- Indian Organic Chemicals Research Fellow, UDCT,Matunga,Mumbai (4 yrs,academic experience)
JOB PROFILE: To carry out research and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents , Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.
Personal Details :
Location : Mumbai (Thane)
Nationality : Indian
Date of Birth : 17th January, 1964
Marital Status : Married
Postal address : Vijay Nagari Annex, Bldg.26, Flat 34
Ghodbunder Road, Thane (W)-400 615 India.
Email I.D. [email protected]
Web : http://amcrasto.weebly.com/ http://newdrugapprovals.org/ (ctrl +click to follow link)
Residence. Tel +91-22-5972567/
Mobile :+91(country code)-9323115463/+91-9321316780
EDUCATION:
Ph.D – Organic Univ.Department of Chemical Technology, Matunga By Research
Chemistry – (1991) Bombay (Univ. of Bombay) India Thesis : Prof. S.Seshadri
Synthesis of Novel Pyrethroid Analogues.
M.Sc. - (Organic R. J. College, Ghatkopar, Securing 1st Class
Chemistry – (1986) Bombay (Univ. of Bombay) (65.50%)
B.Sc -.Chemistry R .J. College, Ghatkopar, Securing 1st Class
(1984) Bombay (Univ. of Bombay) (62.60%)
H.Sc (1981) R. J. College, Ghatkopar, Securing 1st Class
Bombay (Poona Board) (68.17%)
S.S.C (1979) St. Xavier`s high School, Securing 1st Class
Powai, Bombay (Poona Board) (69.29%)
OTHER COURSES:
- Part time Certificate course in Basic Computer Programming from Students Computer land – Mulund Bombay (First Class)
- Part time Certificate course in General Electronics from Bombay Inst. Of Tech. – Mulund – Bombay.
- Postgraduate Diploma Course in Industrial and Analytical Chemistry from Ruia College – Matunga (1986-1987 – Grade A)
- Diploma Course in Business Management from Prin-L.N.Welingkar Inst. Of Management, Research & Development, Matunga Bombay (Aug. 1989 – 1990 – Grade A), Courses included:,Marketing Research and Advertising,Marketing Management,Personnel Management,Office Management and Administration,Managerial Economics,Financial and Cost Accounting,Industrial Law,Principles and Practice of Management,Organizational Behavior,Stores Management and Inventory Control
years) total=36yrs
- Presently working with AFRICURE PHARMA as ADVISOR (FEB 2023 -PRESENT) To create value addition to brand AFRICURE, Recommend technical talent, Identify joint ventures between Global companies/Indian and Africure to do business in Africa. Assist in locating tech and identifying to provide tech transfer. Refer Africure to relevant global companies and Indian programmes and get better visibility. Paticipate in aquisitions, mergers, tieup and identify them.
ALSO ROW2TECH, NIPER-G, CLEANCHEM LABS
- Currently serving as Consultant with GLENMARK LIFE SCIENCES LTD research centre, API division at Mahape ,Navi Mumbai, India job involves research and development work on APIs from lab to commercial production, support for DMF filing, in the process develop novel non infringing routes and file patents,(Jan 22-JAN 2023]
- Worked as Principal Scientist, Process research(Bulk Actives) with GLENMARK LIFE SCIENCES LTD research centre, API division at Mahape ,Navi Mumbai, India job involves research and development work on APIs from lab to commercial production, support for DMF filing, in the process develop novel non infringing routes and file patents,(dec05-Jan 22)
- Worked as Sr Manager R&D with Innovassynth technologies Limited, Khopoli, India (formerly IOC ltd) and led a team of 20 chemists for the custom synthesis business in the area of drugs, organic intermediates, specialty chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months)
- Worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle India ltd). Thane Belapur. INDIA The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 6 months )
- Worked as an Executive, process development at German multinational Hoechst Marion Roussel Ltd, (NOW SANOFI-AVENTIS)Mulund, Mumbai, India in the Process Development Team. (Jan1993 - Jan1997, 4 years)
- Worked as an Executive,QA/GMP at a German multinational Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the QA dept, GMP section (Feb.1997 – oct. 1997, 8 months)
- Carried out Synthetic Research work as a Management trainee (R&D) at an American multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life Sciences Ltd) (May 1991 to Dec. 1992, 1 year 7 months)
- Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, for PhD programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”. Simultaneously did project work for IOC.(1987-1991, 4 years) RESEARCH GUIDE PROF S SESHADRI
Highlights in career
- Selected for PH.D programme ,1987 in IIT Mumbai and UDCT, Mumbai(opted for UDCT).
- Awarded Rs.20000/- 1992 for best performance in Hoechst Marion Roussel (HMR), MUMBAI,INDIA.
- Involved in a successful TGA Audit in HMR 1997
- Promoted to Executive, Process Development from Officer in HMR (1996)
- Exported 100Kg. MAPO (RPG) 1998 to CBZ U.K. in 3 months time and later awarded a trip to U.K.
- Promoted from Asst. Manager to Manager (RPG 2000) for commercialization of 25 tons deltamethrin, SPENT SIX MONTHS TIME IN THE PLANT and recd certificate from MD(product instrumental in a gain of 90 crores from sale to isagro limited)
- Manufactured Raloxifene (2 kg.) in a team work in one months time to be registered in U.K. for CBZ U.K.
- Registered Donepezil for the 1st time in India and later on manufactured 4 kg. (2002-03)
- Involved at Innovassynth in commercialization of a dozen projects to the tune of a turnover of 60 crores in the custom synthesis business for reputed foreign clients
- At Innovassynth contributed 2 products in the first year, guggulsterone and BTE which led to construction of a pilot plant worth 22 crores.
- stock options:allotted 70,000 shares of innovassynth under key employee stock option
- Attended international organic chemistry conference in Singapore on 8 dec 2005 -10 dec 2005
- Filed several patents
- Retired Glenmark
- Continued as consultant Glenmark
- Now with Africure Pharma
Expertise in the area of Process R&D (Generic API)
Development of new API for fresh DMF / CEP Filings for Regulated Markets (US, EU, Canada, Japan etc,).ü Expertise in Lab Development of New API for fresh DMF Filing for regulated markets. Execution of pre-scale up, scale-up and exhibit/validation batches of the new API. Technology Transfer from lab scale to kilo lab, Pilot plant scale and finally to plant scale for commercial Production. Process validation at plant scale to file DMF for regulated markets.
Hand on experience in the Cost reduction / Technology improvement of existing DMF filed APIs by Identifying areas of improvement for existing commercialized processes in all divisions with the objective of “increasing throughput, reducing the steps, recovering and recycling of spent solvents, minimizing waste, effluent generation, reducing cycle time, reducing the overheads corrections, recycles and improve process yield, and RM consumption, using cheaper RM’s, by changing the reaction scheme etc.,"
Expertise in plant level trouble shooting and also in trouble free technology development and Technology Transfer of API.
Expertise in Synthesis of impurities and impurities carry over study/ Genotoxic impurities evaluation / Addressing Regulatory / customer deficiency queries.
Well versed with ICH Guidelines, cGMP, USFDA & Regulatory requirements for various advanced markets like EU, US and Japan, also the regulatory requirements for fresh DMF filing and variation filing of existing process with FDA on existing process. Well versed on the DRA requirements on variation filing of the Technology Improved / cost reduction of existing / commercialized / DMF / CEP filed process.
Well versed with Para – IV Filing, FTF and also regulatory requirements for Drug Substances.
Articulate, dynamic leader with diverse blend of Process R&D / Process Improvement / Process development, tech transfer, Scale–up expertise of API. Well versed with QBD and implementing design of experiments for API Experience in training chemists and handlinfg all softwares needed for process research
Presently working with AFRICURE PHARMA as ADVISOR (FEB 2023 -PRESENT)
To create value addition to brand AFRICURE, Recommend technical talent, Identify joint ventures between Global companies/Indian and Africure to do business in Africa. Assist in locating tech and identifying to provide tech transfer. Refer Africure to relevant global companies and Indian programmes and get better visibility. Paticipate in aquisitions, mergers, tieup and identify them.
GLENMARK LIFESCIENCES LTD. - JAN ‘22 – JAN 2023API ,PROCESS RESEARCH
Currently with GLENMARK LIFESCIENCES LTD research centre as Consultant API) at Mahape ,Navi Mumbai,(Jan2022-present) and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
GLENMARK LIFESCIENCES LTD. - JAN ‘22 - 16.1 YRS , WorkedAPI ,PROCESS RESEARCH
Worked with GLENMARK LIFESCIENCES LTD research centre as Principal Scientist, process research (bulk actives) API) at Mahape ,Navi Mumbai,(dec05-present) and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
Currently, involved in development of 8 targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects
- Process Development :-
- Providing guidance and support for process development for challenging of patents in regulated market.
- Design patent non-infringing scalable synthetic routes/process and scale-up of API’s
- Bench and Pilot scale synthesis transformations in hands on
- Optimization of the process, ie,developing industrially feasible process.
- Preparation of PDR, filing of patent and DMF
- Lead a group of Scientists and Jr.Group Leaders.
- Hands on with GC, NMR, IR, UV, HPTLC
- Technology Transfer:-
- Preparation of technology transfer document(TTD)
- Validation batches
- Timely transfer of cost effective technology for scale up and commercialization.
- Skill sets:- Technical skills:
- Synthesis:
- Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant
- Conducted various reactions at laboratory and production scales.
- Synthesized various classes of compounds.
- Analytical:
- Excellent skills in the operation and interpretation of analytical data from NMR, IR, UV, GCMS, HPLC, GCMS etc.
- Experienced to work under cGMP condition
- Documentation:
- Literature survey: Should be well conversant with the use of Sci Finder, MS word, MS Excel, Power point, Chem. Draw and Internet search techniques.
- Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.).
- Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products.
- Risk analysis: Evaluating risk in the new business areas and synergize the team to search for alternatives/reduce/avoid risks that have to be assessed well
- Soft skills:-
- Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening
-
INNOVASSYNTH TECHNOLOGIES. 2 .7 Years CUSTOM SYNTHESIS
Worked as Sr Manager (R&D) with Innovassynth technologies Limited, Khopoli, INDIA (formerly IOC Ltd) a custom synthesis company catering to leading American and European Multinationals (May’03 – Dec ‘05, 2 yrs 7 months)
Headed a group and worked on approx 25 custom synthesis projects with 18 scientists /chemists and 2 literature scientists. in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months)
Dozen projects already executed and some in pipeline waiting for commercialization in the old and new pilot plants. ( clients include Bedoukain, CCR, polyfine, Novartis, lonza, Synergy, BASF, Austin, FMC, Crompton, Semafore etc)
projects commercialized : - Guggulsterone
- COENZYME Q10 Intermediate
- N-(2,4 Dimethoxy phenyl) piperazine
- 2,6 -DMPI
- Benzoic acid 4(4-propyl-1- piperazine)
- 2,4- dichloro 5- methoxyaniline
- 2- bromo hexanoic acid
- CCTI
- DMCPA.HCl
- Hexyl resorcinol
- Several in pipeline for commercialization
- 60 samples sent for evaluation to foreign clients
-
RPG LIFE SCIENCES LTD. 5 Yrs/7Months API/CUSTOM SYNTHESIS
Worked as a Manager (R&D) at RPG Life Sciences Ltd (formerly American multinational SEARLE INDIA LIMITED,. Thane Belapur. India. The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 7 months )
PROJECTS HANDLED AT RPG Life sciences ltd(Drugs, Drug intermediates,Agrochemicals, intermediates for custom synthesis)
PHARMACEUTICALS:
1. Donepezil Manufactured 4 kilos on pilot plant scale as R & D
demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins
2. Pantoprazole Process is being modified continuously to cope-up with
price crash
3. PZL. Chloride an Multi-step process is being continuously modiied intermediate of /developed to meet cost demands.
Pantoprazole
4. Cilostazole process development development
5. Gatifloxacin Developed a process which was not commercialized due
to cheap drug available from china.
6. Raloxifene Was involved in the scale up team supporting rapid
commercialization of the drug.
7. Chiral Piperazine Developed this intermediate of indinavir
8. Int. of Glimepiride Developed 3 – ethyl – 4 methyl – 3 pyrrolidine – 2 one
AGRO
1. Deltamethrin manufactured 3 tonnes on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie lit,lab work, scale-up, pilot trials and also included third party work. Later on annually about 25 tonnes were manufactured.
(Stayed in plant for a period of 6 months to complete 3 tons campaign and received award from managing director)
2. Acetamiprid Developed a process from scratch. Process was handed over to isagro for commercialization in 2001
during hiving of the company from RPG
3. M-alcohol an During isagro transition period in 2001, the process
intermediate from Italy was adapted to Indian plant conditions,
of Tetra conazole scaled up with some modification and handed over for
commercialization. This is being produced on a regular
basis.
4. Pyrazosulfuron ethyl Developed a process from scatch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG.
intermediates (custom synthesis)
1. Thiol-intermediate Manufactured 2 kilos on pilot plant scale as R & D
of raloxifene demonstration. (for CBZ-U.K.)
2. TPCP Manufactured 1 kilo in lab (Aventis – Germany)
4 Phenyl – 4 Piperidine carboxylic acid tosylate(TPCP)
3. DBAP Manufactured 0.250 kilo in lab (Aventis –Germany)
Ethyl 3 (N-3,4 Dimethoxybenzyl)amino-propionate
4. MAPO Methyl aziridine phoshonium oxide 100kg. in pilot
plant (CBZ – U.K.)
5. 6 HDHQ Int. of Manufactured 0.250 kilo in lab (Davos – USA)
cilostazole
6. p-Triflouromethyl Maufactured 1 kg. for Rhodia – France
7. 6 MDHQ Manufactured 0.5 kg. for Davos
HOECHST MARION ROUSSEL(GMP DEPT) 7 months PHARMA
Worked as an Executive with GMP/QA DEPT. in HOECHST MARION ROUSSEL LIMITED Mulund, Mumbai(1997 Feb to Oct. 1997—8 MONTHS)
QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES
1. Exposure to GMP in Bulk drugs and Formulations
2. Excellent Computer literacy.
3. Prepared Drug master files and Site master files for submission to Foreign
and Local regulatory bodies.
4. Conducted Process validations of Bulk drugs.
5. Exposure to cleaning validations.
6. Reviewing of SOP's for different departments.
7. Reviewing of MFR's and BMR's
8. All aspects of documentation with respect to GMP guidelines.
9. Involved in a successful preparation for an audit by the Australian
regulatory body." Therapeutic Goods Administration (TGA) "
10. Similar involvement with a WHO audit of formulations.
11. Conducted several GMP audits.
12. Conducted several Vendor assessments.
MANUFACTURING
Practical Production Training in Pharmaceutical manufacturing in the following Departments.
1 Powder injectibles
2 Large Volume Parenterals (Haremaccel)
3. Small Volume Parenterals (Liquid injectibles)
4. Tablets.HOECHST MARION ROUSSEL(PROCESS. DEVELOPMENT) 4YRS PHARMACEUTICALS
Worked as an Executive in the Process Development Team. At HOECHST MARION ROUSSEL (Mulund, Mumbai).(now sanofi-aventis) (Jan1993 - Jan1997, 4 years)
PROJECTS HANDLED:
1. Pentoxyfylline Independently developed a new route
2. Roxatidine In a team worked on some of its intermediates.
3. Deltamethrin Process developed and production trouble shooting
4. ECPPA Independently developed a 5 step route for the synthesis
of this single isomer(Enalapril/Ramipril)
5. Furamethrin Alc Independently developed a commercially viable route for
its manufacture involving Acetylene as the raw material
6. Tefuramethrin Independently developed its synthesis for M/S Diannihon
Jochugiko Japan
7. Several Drugs/ Trouble shooting for production (e.g. Pitofenone HCI
Frusemide Ramipril etc.)
SEARLE INDIA LIMITED ( R & D DEPT) 1yr/7 months PHARMAWorked as management trainee at SEARLE INDIA LIMITED(American multinational) (May 1991 to Dec. 1992, 1 year 7 months)(Drugs and Natural products )
RESEARCH GROUP :
Worked with Dr.K. Nagarajan and Dr. (Mrs.) S.J. Shenoy
1. Azathioprine Partially workded on all the steps without having
much exposure on the projcect
2. Cis – Menthadienol In a team worked on a 6 step stereospecific synthesis
3. Trans-Menthadienol In a team isolated it from Ginder grass oil in its
pure form
4. Olivetol In a team worked on its 3 step synthesis
5. Iothalamic acid In a team worked on its process development
6. Diatrizoic acid In a team worked on its process development
7. Iopamidol In a team worked on its process development
ICT MATUNGA MUMBAI, INDIA .(1987-1991, 4 years)
Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, for PhD programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”. - Simultaneously did project work for IOC.(1987-1991, 4 years)
- RESEARCH GUIDE. PROF S SESHADRI
-
RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER
1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity. - Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.
- Worked as a technology transfer man and provide all data required for transfer from lab to commercialization.
- Assist in stability studies/impurity profiles/dossiers and act as a coordinator between lab and commercial production. Also required to synthesize some impurities in pure form to meet the dossier demands.
- Complete command for use of computer, ability to use all programs( word,excel,powerpoint) and no need for secretarial assistance.
- Use of Internet and manual literature search methods to decide the synthetic strategy and upgrading of literature information for existing entities. Well versed with CAS scifinder program for literature search. Also having the ability to look for free information on the web( patents, etc). well versed with use of a german program for lit search ie spresiweb,ability to handle programs like integrity etc
- Use of modern spectroscopy/analytical methods to monitor the synthetic scheme.
- Guide a team of chemist/technologists during commercialization.
- Use of GLP/GMP wherever required i.e. lab, pilot plant, plant and maintain documentation as per norms applicable.
- Assist the technologist during unit operations during manufacture.
- Strictly follow the safety norms, educate and implement the safety
- Procedure as per norms, conduct hazop studies.
- Training and development of fresh chemists and up-gradation of skills of existing ones, Maintain a cogenial atmosphere for the team and encourage team work.
- Finally look for excellent standards of working, which will minimize reworks / cost and maximize output.
- Excellent ability to understand and communicate to foreign customers via email, documents and telephone. Maintain good documentation in this respect. Excellent presentation skills for presenting to top management or clients.
- Ability to work with original inventor in US and the drug company needing the final product in Europe, eg coenzyme q10 . Interact with both of them and produce results acceptable to both.
- Maintain confidentiality and stick to the agreement.
- Write DHR for API before implementation of novel route in the plant and assist for all batches for the DMF purposes, very well versed with IPR issues
- Ability to develop novel routes for API,s and draft patents,well versed with polymorphism issues
- Ability to evaluate new products before taking up in lab/ pilot/manufacturing
- Well versed with all softwares incuding ones for DOE
- Abilty to check solvent volumes, hazardous chem and existing reagents and suggest correct ones
- Ability to cut costs of API development and time
- Ability to evaluate a new molecule for process development in R and D team
- Ability to generate export import data for a molecule
- Ability to generate rough paper costing for new molecule launches
- Ability to scan literature to check new patents weekly for generic or new discovery molecules
- Abilty to synthesize impurities needed for development
- Understand requirement of regulatory, analytical and stabilty data for Anda launch
- Understand and execute api requirement for para four filing
- To train chemists all round
- Qbd, doe implementation
- Now consultant Glenmark
- AND ALSO AFRICURE, ROW2TECH, NIPER-G, CLEANCHEM LABS
PATENTS
Process for the preparation of atovaquone
United States US20090105350
October 9, 2008
Process for the preparation of tadalafil
Europe WO 2007110734
PCT Application WO2007110734 | Filed: 03/23/2007 |...
Amorphous eprosartan mesylate and process for the preparation thereof
United States US20080014263
Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation
Europe WO 2012007959
Issued January 2012
Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
Europe WO 2011158250
Issued December 22, 2011
Amorphous eprosartan mesylate and process for the preparation thereof
United States US 20080014263
Issued January 17, 2008
AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF
United States US 20100310870
A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE
India INDIAN PAT Ref. No: Appl No.243/BOM/1999 A, Year: 01/1999
Issued January 1, 1999
IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL
India INDIAN PAT Ref. No: 1135/MUM/2006
Issued July 18, 2008
A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE
India Ref. No: 1742/MUM/2007 A, Year: 01/2009
Issued January 1, 2009Awards
All my awards
http://amcrasto.weebly.com/awards.html
Anthony melvin Crasto
"100 Most Impactful Health care Leaders Global listing", conferred at Taj lands end, Mumbai, India on 14 Feb 2017 by World Health Wellness congress and awards
“Best Worlddrugtracker “ Award for lifetime acheivement in Pharma... 7 th July 2017 , The venue...Taj land ends, Bandra, Mumbai India
“Lifetime achievement award” WORLD HEALTH CONGRESS 2017 in Hyderabad, 22 aug 2017 at JNTUH KUKATPALLY. HYDERABAD, TELANGANA, INDIA,
" Lifetime Achievement Award", at the The Middle East Healthcare Leadership Awards - 12th October, 2017 -The Address, Dubai Mall, Dubai...UAE..........Mohammed Bin Rashid Boulevard, Downtown Dubai - Dubai - United Arab Emirates
International award for Outstanding contribution in Pharma at World Health and wellness Congress award, 14th Feb, 2018, at Taj Lands ends, Bandra, Mumbai, India
Conferred very prestigious IDMA award for contribution to society in Pharma at INDIAN DRUGS ANNUAL DAY 2018 VMCC IITBombay Powai, Mumbai India 22 Feb 2018,I was Guest of honor at and was felicitated by president,Indian Drug manufacturers association (IDMA)
Award conferred The Golden Globe Tigers Awards 2018, for Excellence in Pharma, at kuala lumpur, Malaysia, 23 april 2018 at Pullman hotel.
Conferred prestigious individual national award at function for contribution to Pharma society from Times Network, National Awards for Marketing Excellence ( For Excellence in HEALTHCARE) | 5th July, 2018 | Taj Lands End, Mumbai INDIA
Conferred award for Excellence in Pharma by CMO ASIA Award 31st July - 1st August, 2018 | Le Méridien Singapore, Sentosa
Life time Achievement Award by Bioleagues at 4th World Summit on Pharmaceutics Drug Designs, Dubai, UAE. Sep 21-22, 2018 at Flora creek Dubai UAE
Conferred prestigious ABPnews award for "Outstanding contribution to Education Sector" at event ABP News Presents Healthcare Leadership Awards 26th November, 2018 at Taj Lands End, Mumbai India
Honoured to get Award by ETnow for Outstanding contribution to social service at ET Now Presents World Mental Health Congress Co - Hosted with World Health & Wellness Awards, 15th February, 2019. | Taj Lands End, Mumbai, India
Honoured to get prestigious "SPER Innovative Researcher Award" The award was given in the SPER 8th Annual International Conference & Exhibition [SPER 2019] at VYWS’S Inst of pharma education and Research, Wardha [Maharashtra] India on February 23, 2019
Life time Achievement award at BioLEAGUES Worldwide at the 5th International Conference on Pharmaceuticals, API & Mfg. with the theme Enabling Technologies for API, Formulation & Manufacturing Aston Priority Simatupang Hotel & Conference Center, Jakarta, Indonesia on March 15th, 2019.
Lifetime achievement award, Prisal, Bhopal MP, India 26 may 2019 National Pharma Conference organized by Prisal, Pharmaceutical Royal International Society on Pharmaceuticals: Bench to Bedside: Challenges, Recent Initiatives & Future Perspectives
venue, State level animal husbandry auditorium, Bhopal
Honoured to be conferred LIFE TIME ACHIEVEMENT AWARD by LOQMAN AWARDS ( National & International Awards ) on 23rd June 2019 Hotel Saffron leaf, Dehradun, Uttarakhand , India
Honoured to be conferred Outstanding contribution to Healthcare and Social cause, at “Global Healthcare & Medical Tourism Conclave” 4 th Oct 2019, at ITC Maratha, Mumbai, India,
Lifetime achievement award, conferred at Hotel Flora creek, Dubai, UAE
Organized by Bellemie presents Golden Global Health & Education INTERNATIONAL Conference & Awards 🥇 2019 held on 16th November 2019 at Hotel Flora Creek Dubai UAE
LIFETIME ACHIEVEMENT AWARD conferred by ABP News at ABPNEWS Presents Health Care Leadership Awards 20th November 2019 at Taj Lands End, Mumbai India, Award given by Mr Shailesh Hedge of ABPNEWS, Mr Daara patel, IDMA, Mr Sudarshan jain, IPA, Dr. R L Bhatia Chief Editor & Founder @World CSR Day; Dr Tarita Shankar Chief Managing Trustee SCES
Conferred most prestigious International award at INTERNATIONAL ICONIC AWARD'S 2019 SEASON - 5, Entitled "International lconic Excellent Contribution To Social Services and Education" at The Club, DN nagar , Andheri west, Mumbai India 25th Nov 2019
Thanks to M Nagaman and Nisha rawal for giving the honor
Life time achievement award and Guest of honor status at *Operant Pharmacy Federation* Presenting *World Congress on Pharmaceutical Sciences* on 02-03 December 2019, at Bengkok, Thailand 🇹🇭 with the theme *Empowering New Era Technologies in Pharmaceutical Sciences* Venue: Avani Atrium Bangkok
1880 New Petchburi Road, Bangkapi, Huay Kwang, Bangkok, Thailand
Conferred ETNOW news presents 101 most fabulous healthcare leaders, Global listing
at Tajlands end, Bandstand, Bandra (W), Mumbai 400 050, Mumbai, India
14th Feb 2020, Honour by world health and wellness congress
WOCKHARDT FOUNDATION , SIR DR HUZ KHORAKIWALA TO ANTHONY CRASTO , CONFERRED TITLE AS “WORLD PEACE AMBASSADOR” 20th March , Friday
Dr. Anthony Melvin Crasto Glenmark is now world peace ambassador
SAS Lifetime achievement award 2020 by SAS society
SAS Society has announced "SAS International Awards 2020". #SAS Life time Achivement Awardee 2020. http://www.sassociety.com/sas-conference-and-awards-2020/
Exploring Scholars to Success, ANNOUNCEMENT: SAS INTERNATIONAL AWARDS 2020
Guwahati, Assam, August 03, 2020
WOCKHARDT FOUNDATION AWARD AT ORCHID MUMBAI INDIA 28 JAN 2021
World peace Ambassador Conferred by DR Huzaifa Khorakiwala executive director WockhardtI was physically present to take the award
The Orchid Hotel Mumbai Vile Parle
70-C, Nehru Rd, near Mumbai Domestic airport, Navpada, Vile Parle East, Vile Parle, Mumbai, Maharashtra 400099.
https://goo.gl/maps/vgTNYHwQr3AU2VnF9
Award for Asia pacific excellence award. Title is Life time achievement award
Belgave education society. Commonwealth international university
Gera global education, Research alliance. 30th may 2021 Hotel Radisson Blu. New delhi. Rescheduled to 11th July 2021
Life time achievement award, cooor 27 aug 2021, Holiday inn, mumbai, India
Physical presence event. Award function 27 aug 2021 Award for "Life time achievement award" by Cooor. Council for Brand business promotions and Research in collaboration with News1 India and MSME chamber of commerce and industry 27th aug 2021 at Holiday Inn. Mumbai India
Award received online and speedpost, BHARAT SHIKSHA GAURAV PURASKAR
said prestigious “BHARAT SHIKSHA GAURAV PURASKAR” and a “CERTIFICATE OF EDUCATION EXCELLENCE”. KTK Outstanding Achievers and Education Foundation in association with Helium production
Sunday Nov 14 2021 as virtual event in New delhi
Online 20th Feb 2022 New Delhi India
Lifetime achievement award recieved today from ktk foundation, Life time achievement award 2022
KTK Outstanding Achievers and Education Foundation in association with Helium Production presents lifetime achievement award for industry academic interaction in education, Virtual ceremony 20th Feb 2022 New Delhi
Life time achievement award, At Indore 2nd April 2022 Pharmanest, Operant Pharmacy Federation,
International Conference On Post Covid Era , An International conference on pharma at Radisson Blu Indore india
Life time achievement award from Hon Dr Kiran bedi IPS Governor of puducherry
I was Special guest too at Brand council ratings Conclave and awards 2022 at Holiday Inn, Mumbai India on 16th April 2022, In association with News india 1, The Most Prestigious Healthcare Summit " 4th Edition- South Asia Pacific Healthcare Summit and Business Awards 2022", Www.medilinksindia.com/awards
'Top 10 Prominent & Great Personalities of the year 2022' campaign by Fame Finders. 16 JAN 2023
Feeling great to be selected in the 'Top 10 Prominent & Great Personalities of the year 2022' campaign by Fame Finders. It is an online campaign to honour inspiring personalities and feature them in the upcoming edition of the top news sites, including - Deccan Chronicle/Asian Age/Deccan Herald, ANI, Zee5, Latestly, Lokmat Times, DailyHunt, Google News, JioNews, MSN
and 70+ sites. LINK https://www.deccanherald.com/brandspot/pr-spot/top-10-prominent-and-great-personalities-of-the-year-2022-announced-by-fame-finders-media-1181964.html
Proud to recieve Indira Diversity award 2023 for never give up attitude in life, 21 Jan 2023. Indira institute Pune India, Indira Diversity Awards-2023", to witness the presence of super achievers who have contributed to our country's glory, along with organizations that have celebrated inclusivity and diversity,
Weece Global Awards 2023, Feb 15 2023, Honoured to get Lifetime achievement award, Hyat Centric New Delhi India, At GlobalPHT 2023
Biography
READ MY BIOGRAPHY..........http://scijourno.com/2017/01/09/dr-anthony-crasto/ Written by Mr. Amrit B. Karmarkar
Director, InClinition